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Members of the immunoglobulin superfamily in bacteria
Author(s) -
Bateman Alex,
Chothia Cyrus,
Eddy Sean R.
Publication year - 1996
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560050923
Subject(s) - immunoglobulin superfamily , superfamily , bacteria , antibody , immunoglobulin g , computational biology , microbiology and biotechnology , biology , genetics , gene
Abstract We report a prediction that two prokaryotic proteins contain immunoglobulin superfamily domains. Immunoglobulin‐like folds have been identified previously in prokaryotic proteins, but these share no recognizable sequence similarity with eukaryotic immunoglobulin superfamily (IgSF) folds, and may be the result of the physics and chemistry of proteins favoring certain common folds. In contrast, the prokaryotic proteins identified have sequences whose match to the immunoglobulin superfamily can be detected by hidden Markov modeling, BLASTP matches, key residue analysis, and secondary structure predictions. We propose that these prokaryotic immunoglobulin‐like domains are almost certain to be related by divergence from a common ancestor to eukaryotic immunoglobulin superfamily domains.