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Crystals of the neurotrophins
Author(s) -
Robinson Robert C.,
Stuart David I.,
Yvonne Jones E.,
Radziejewski Czeslaw
Publication year - 1996
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560050520
Subject(s) - neurotrophin , neurotrophin 3 , crystallization , nerve growth factor , brain derived neurotrophic factor , biology , neurotrophic factors , chemistry , biochemistry , receptor , organic chemistry
The neurotrophins show a high degree of amino acid sequence homology, share similar solution properties, and display distinct but parallel functionalities. Here we report the crystallization and preliminary X‐ray characterization of three neurotrophins: brain‐derived neurotrophin, neurotrophin 3, and the heterodimer between brain‐derived neurotrophin and neurotrophin 4. These findings are related to other published crystal parameters for neurotrophins, leading to the observation that, although crystal packing is highly variant, neurotrophins share common solubilities with respect to crystal growth.