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On the entropy of protein folding
Author(s) -
Makhatadze George I.,
Privalov Peter L.
Publication year - 1996
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560050312
Subject(s) - protein folding , physics , computational biology , statistical physics , chemistry , biology , nuclear magnetic resonance
The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.
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