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The protein machinery of vesicle budding and fusion
Author(s) -
Rothman James E.
Publication year - 1996
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560050201
Subject(s) - endocytosis , vesicle , microbiology and biotechnology , vesicular transport protein , transport protein , intracellular , budding , biology , intracellular transport , chemistry , cell , biochemistry , membrane
A general protein machinery that buds and fuses transport vesicles is harnessed to generate the complex web of intracellular transport pathways critical for such diverse processes as cell growth, endocytosis, hormone release, and neurotransmission. With this appreciation, the challenge of understanding the precise molecular mechanisms of these many facets of cell biology has been reduced to a series of problems in protein structure and chemistry.