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Ethanol utilization regulatory protein: Profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion
Author(s) -
Nicholas Hugh B.,
Persson Bengt,
Jörnvall Hans,
Hempel John
Publication year - 1995
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560041221
Subject(s) - alcohol dehydrogenase , aldehyde dehydrogenase , ethanol , alcohol , gene , fusion protein , chemistry , biochemistry , fusion , fusion gene , aldh2 , genetics , alcohol oxidoreductase , biology , enzyme , nad+ kinase , recombinant dna , linguistics , philosophy
The suggestion that the ethanol regulatory protein from Aspergillus has its evolutionary origin in a gene fusion between aldehyde and alcohol dehydrogenase genes (Hawkins AR, Lamb HK, Radford A, Moore JD, 1994, Gene 746 :145‐158) has been tested by profile analysis with aldehyde and alcohol dehydrogenase family profiles. We show that the degree and kind of similarity observed between these profiles and the ethanol regulatory protein sequence is that expected from random sequences of the same composition. This level of similarity fails to support the suggested gene fusion.