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Structural features of the uniporter/symporter/antiporter superfamily
Author(s) -
Goswitz Visala Chepuri,
Brooker Robert J.
Publication year - 1995
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560040319
Subject(s) - symporter , antiporter , transmembrane protein , superfamily , transmembrane domain , uniporter , antiporters , transporter , biophysics , chemistry , microbiology and biotechnology , biology , biochemistry , computational biology , membrane , receptor , gene , enzyme , cytosol
The uniporter/symporter/antiporter superfamily is an evolutionarily related group of solute transporters. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains. These transmembrane domains were then analyzed with regard to their overall hydrophobicity and amphipathicity. In addition, the lengths of the hydrophilic loops connecting the transmembrane domains were calculated. These data, together with structural information in the literature, were collectively used to produce a general model for the three‐dimensional arrangement of the transmembrane domains.