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Influenza virus neuraminidase: Structure, antibodies, and inhibitors
Author(s) -
Colman P.M.
Publication year - 1994
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.5560031007
Subject(s) - neuraminidase , virology , virus , antibody , antigen , original antigenic sin , antigenic shift , influenza a virus , biology , antigenic drift , antigenic variation , h5n1 genetic structure , enzyme , orthomyxoviridae , medicine , immunology , biochemistry , disease , covid-19 , infectious disease (medical specialty) , pathology
Abstract The determination of the 3‐dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti‐influenza virus drug.