The curious case of protein splicing: Mechanistic insights suggested by protein semisynthesis | Zendy

Wallace CARMICHAEL J.A. | Zendy

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The curious case of protein splicing: Mechanistic insights suggested by protein semisynthesis

Author(s) -

Wallace CARMICHAEL J.A.

Publication year - 1993

Publication title -

protein science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.353

H-Index - 175

eISSN - 1469-896X

pISSN - 0961-8368

DOI - 10.1002/pro.5560020501

Subject(s) - semisynthesis , rna splicing , mechanism (biology) , biology , computational biology , protein evolution , protein splicing , phenomenon , alternative splicing , evolutionary biology , sequence (biology) , genetics , gene , exon , biochemistry , rna , philosophy , epistemology

The gradual accumulation of examples of protein splicing, in which a nested intervening sequence is spliced out of the interior of a polyprotein precursor, suggests that this curious phenomenon might prove to have universal phylogenetic distribution and biological significance. The known examples are reviewed, with the aim of establishing underlying patterns, and a generalized mechanism of autocatalytic protein splicing is proposed. The testable consequences of such a proposal and the possible evolutionary origins of the phenomenon are discussed.

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