Premium
Cover Image
Publication year - 2021
Publication title -
protein science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.4063
Subject(s) - cover (algebra) , enzyme , phylogenetic tree , image (mathematics) , combinatorics , computer science , information retrieval , biology , crystallography , stereochemistry , computational biology , chemistry , mathematics , genetics , artificial intelligence , biochemistry , mechanical engineering , engineering , gene
Enzyme promiscuity is regarded as a key driving force for the evolution of new enzyme functions, and ancestral sequences reconstruction is a powerful tool to investigate the appearance of enzymatic functions in natural enzyme lineages. In this cover image, some techniques used to characterize an ancestral enzyme are represented–an X‐ray crystallography pattern and a phylogenetic tree where the ancestral enzyme structure emerges. The substrates tested in the article are shown as sticks; pyridoxal (vitamin B6) in yellow and hydroxymethyl pyrimidine (vitamin B1 intermediate) in orange. See article by Gonzalez‐Ordenes et al., pp. 842‐854.