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High‐resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels
Author(s) -
Goor Mark K.,
Jager Leanne,
Cheng Yifan,
Wijst Jenny
Publication year - 2020
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3861
Subject(s) - transient receptor potential channel , trpv , ion channel , gating , trpc1 , ankyrin , biophysics , chemistry , trpm2 , neuroscience , microbiology and biotechnology , trpv1 , biology , receptor , biochemistry , gene
Abstract Transient receptor potential vanilloid (TRPV) channels are part of the superfamily of TRP ion channels and play important roles in widespread physiological processes including both neuronal and non‐neuronal pathways. Various diseases such as skeletal abnormalities, chronic pain, and cancer are associated with dysfunction of a TRPV channel. In order to obtain full understanding of disease pathogenesis and create opportunities for therapeutic intervention, it is essential to unravel how these channels function at a molecular level. In the past decade, incredible progress has been made in biochemical sample preparation of large membrane proteins and structural biology techniques, including cryo‐electron microscopy. This has resulted in high resolution structures of all TRPV channels, which has provided novel insights into the molecular mechanisms of channel gating and regulation that will be summarized in this review.