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Miro: A molecular switch at the center of mitochondrial regulation
Author(s) -
Eberhardt Emily L.,
Ludlam Anthony V.,
Tan Zhenyu,
Cianfrocco Michael A.
Publication year - 2020
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3839
Subject(s) - endoplasmic reticulum , microbiology and biotechnology , organelle , mitochondrion , microtubule , cytoskeleton , biology , orchestration , actin , function (biology) , cell , genetics , art , musical , visual arts
The orchestration of mitochondria within the cell represents a critical aspect of cell biology. At the center of this process is the outer mitochondrial membrane protein, Miro. Miro coordinates diverse cellular processes by regulating connections between organelles and the cytoskeleton that range from mediating contacts between the endoplasmic reticulum and mitochondria to the regulation of both actin and microtubule motor proteins. Recently, a number of cell biological, biochemical, and protein structure studies have helped to characterize the myriad roles played by Miro. In addition to answering questions regarding Miro's function, these studies have opened the door to new avenues in the study of Miro in the cell. This review will focus on summarizing recent findings for Miro's structure, function, and activity while highlighting key questions that remain unanswered.