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MarR family proteins are important regulators of clinically relevant antibiotic resistance
Author(s) -
Beggs Grace A.,
Brennan Richard G.,
Arshad Mehreen
Publication year - 2020
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3769
Subject(s) - efflux , repressor , antibiotics , biology , antibiotic resistance , bacteria , transcription factor , microbiology and biotechnology , transcription (linguistics) , genetics , multiple drug resistance , protein family , bacterial genetics , multidrug resistance associated proteins , computational biology , gene , transporter , atp binding cassette transporter , escherichia coli , philosophy , linguistics
There has been a rapid spread of multidrug‐resistant (MDR) bacteria across the world. MDR efflux transporters are an important mechanism of antibiotic resistance in many pathogens among both Gram positive and Gram negative bacteria. These pumps can recognize a variety of chemically and structurally different compounds, including innate and clinically administered antibiotics. Intriguingly, these efflux pumps are often regulated by transcription factors that themselves bind a diverse set of substrates thereby allowing them to regulate the expression of their cognate MDR efflux pumps. One significant family of such transcription factors is the Multiple antibiotic resistance Repressor (MarR) family. Members of this family are well conserved across different bacterial species and in some cases are known to regulate vital bacterial functions. This review focusses on the role of MarR family transcriptional factors in antibiotic resistance within a select group of clinically relevant pathogens.