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The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
Author(s) -
Misas Elizabeth,
Escandón Patricia,
McEwen Juan G.,
Clay Oliver K.
Publication year - 2019
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3727
Subject(s) - biology , repressor , regulator , genetics , protein domain , computational biology , gene , transcription factor
The LUFS domain (LUG/LUH, Flo8, single‐strand DNA‐binding protein [SSBP]) is a well‐conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci ., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris .