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Polycomb repressive 2 complex—Molecular mechanisms of function
Author(s) -
Kouznetsova Valentina L.,
Tchekanov Alex,
Li Xiaoming,
Yan Xiaowen,
Tsigelny Igor F.
Publication year - 2019
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3647
Subject(s) - prc2 , epigenetics , polycomb group proteins , biology , computational biology , transcription factor , function (biology) , transcription (linguistics) , genetics , microbiology and biotechnology , ezh2 , gene , repressor , linguistics , philosophy
Numerous molecular processes conduct epigenetic regulation of protein transcription to maintain cell specification. In this review, we discuss molecular mechanisms of the Polycomb group of proteins and its enzymatic role in epigenetics. More specifically, we focus on the Polycomb repressive complex 2 (PRC2) and the effects of its repressive marker. We have compiled information regarding the biological structure and how that impacts the stability of the complex. In addition, we examined functions of the individual core proteins of PRC2 in relation to the accessory proteins that interact with the complex. Lastly, we discuss the implications of unregulated and downregulated PRC2 activity in Alzheimer's disease and cancer and possible methods of treatment related to PRC2 regulation.