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What has de novo protein design taught us about protein folding and biophysics?
Author(s) -
Baker David
Publication year - 2019
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3588
Subject(s) - protein folding , protein design , computational biology , folding (dsp implementation) , protein engineering , protein structure prediction , protein structure , biophysics , chemistry , nanotechnology , biology , engineering , microbiology and biotechnology , biochemistry , materials science , electrical engineering , enzyme
Recent progress in de novo protein design has led to an explosion of new protein structures, functions and assemblies. In this essay, I consider how the successes and failures in this new area inform our understanding of the proteins in nature and, more generally, the predictive computational modeling of biological systems.