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Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters
Author(s) -
Zhang Xuejun C.,
Liu Min,
Lu Guangyuan,
Heng Jie
Publication year - 2018
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3355
Subject(s) - antiporters , multiple drug resistance , mechanism (biology) , transporter , computational biology , drug resistance , biology , chemistry , bioinformatics , biochemistry , genetics , physics , gene , quantum mechanics
Multidrug resistance (MDR) presents a growing challenge to global public health. Drug extrusion transporters play a critical part in MDR; thus, their mechanisms of substrate recognition are being studied in great detail. In this work, we review common structural features of key transporters involved in MDR. Based on our membrane potential‐driving hypothesis, we propose a general energy‐coupling mechanism for secondary‐active antiporters. This putative mechanism provides a common framework for understanding poly‐specificity of most—if not all—MDR transporters.