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Integrative structure modeling with the Integrative Modeling Platform
Author(s) -
Webb Benjamin,
Viswanath Shruthi,
Bonomi Massimiliano,
Pellarin Riccardo,
Greenberg Charles H.,
Saltzberg Daniel,
Sali Andrej
Publication year - 2018
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3311
Subject(s) - computer science , suite , key (lock) , software , function (biology) , model building , data science , systems engineering , software engineering , engineering , biology , physics , programming language , computer security , archaeology , evolutionary biology , history , quantum mechanics
Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use.