Premium
Clustal Omega for making accurate alignments of many protein sequences
Author(s) -
Sievers Fabian,
Higgins Desmond G.
Publication year - 2018
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3290
Subject(s) - executable , multiple sequence alignment , computer science , benchmark (surveying) , sequence alignment , omega , r package , computational biology , variety (cybernetics) , protein structure prediction , protein structure , bioinformatics , data mining , biology , artificial intelligence , computational science , programming language , peptide sequence , genetics , geography , physics , cartography , biochemistry , quantum mechanics , gene
Clustal Omega is a widely used package for carrying out multiple sequence alignment. Here, we describe some recent additions to the package and benchmark some alternative ways of making alignments. These benchmarks are based on protein structure comparisons or predictions and include a recently described method based on secondary structure prediction. In general, Clustal Omega is fast enough to make very large alignments and the accuracy of protein alignments is high when compared to alternative packages. The package is freely available as executables or source code from www.clustal.org or can be run on‐line from a variety of sites, especially the EBI www.ebi.ac.uk .