Premium
DichroMatch at the protein circular dichroism data bank (DM@PCDDB): A web‐based tool for identifying protein nearest neighbors using circular dichroism spectroscopy
Author(s) -
Whitmore Lee,
Mavridis Lazaros,
Wallace B.A.,
Janes Robert W.
Publication year - 2018
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.3207
Subject(s) - circular dichroism , protein data bank , protein structure , spectroscopy , crystallography , chemistry , physics , biochemistry , quantum mechanics
Circular dichroism spectroscopy is a well‐used, but simple method in structural biology for providing information on the secondary structure and folds of proteins. DichroMatch (DM@PCDDB) is an online tool that is newly available in the Protein Circular Dichroism Data Bank (PCDDB), which takes advantage of the wealth of spectral and metadata deposited therein, to enable identification of spectral nearest neighbors of a query protein based on four different methods of spectral matching. DM@PCDDB can potentially provide novel information about structural relationships between proteins and can be used in comparison studies of protein homologs and orthologs.