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Modeling repetitive, non‐globular proteins
Author(s) -
Basu Koli,
Campbell Robert L.,
Guo Shuaiqi,
Sun Tianjun,
Davies Peter L.
Publication year - 2016
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.2907
Subject(s) - globular cluster , globular protein , physics , computational biology , biophysics , chemistry , biology , astronomy , biochemistry , stars
Abstract While ab initio modeling of protein structures is not routine, certain types of proteins are more straightforward to model than others. Proteins with short repetitive sequences typically exhibit repetitive structures. These repetitive sequences can be more amenable to modeling if some information is known about the predominant secondary structure or other key features of the protein sequence. We have successfully built models of a number of repetitive structures with novel folds using knowledge of the consensus sequence within the sequence repeat and an understanding of the likely secondary structures that these may adopt. Our methods for achieving this success are reviewed here.