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One ring to rule them all: Current trends in combating bacterial resistance to the β‐lactams
Author(s) -
King Dustin T.,
Sobhanifar Solmaz,
Strynadka Natalie C. J.
Publication year - 2016
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.2889
Subject(s) - antibiotics , lactam , antibiotic resistance , bacteria , beta lactam , microbiology and biotechnology , biology , chemistry , genetics , stereochemistry
From humble beginnings of a contaminated petri dish, β‐lactam antibiotics have distinguished themselves among some of the most powerful drugs in human history. The devastating effects of antibiotic resistance have nevertheless led to an “arms race” with disquieting prospects. The emergence of multidrug resistant bacteria threatens an ever‐dwindling antibiotic arsenal, calling for new discovery, rediscovery, and innovation in β‐lactam research. Here the current state of β‐lactam antibiotics from a structural perspective was reviewed.