Structure of the lysine specific protease  K gp from   P   orphyromonas gingivalis , a target for improved oral health | Zendy

Gorman Michael A. | Zendy; Seers Christine A. | Zendy; Michell Belinda J. | Zendy; Feil Susanne C. | Zendy; Huq N. Laila | Zendy; Cross Keith J. | Zendy; Reynolds Eric C. | Zendy; Parker Michael W. | Zendy

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Structure of the lysine specific protease K gp from P orphyromonas gingivalis , a target for improved oral health

Author(s) -

Gorman Michael A.,

Seers Christine A.,

Michell Belinda J.,

Feil Susanne C.,

Huq N. Laila,

Cross Keith J.,

Reynolds Eric C.,

Parker Michael W.

Publication year - 2015

Publication title -

protein science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.353

H-Index - 175

eISSN - 1469-896X

pISSN - 0961-8368

DOI - 10.1002/pro.2589

Subject(s) - porphyromonas gingivalis , virulence , protease , cysteine protease , virulence factor , microbiology and biotechnology , pathogen , chemistry , lysine , biology , amino acid , biochemistry , bacteria , enzyme , gene , genetics

The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell‐surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis . We have determined the X‐ray crystal structure of the lysine‐specific protease domain of Kgp to 1.6 Å resolution. The structure provides insights into the mechanism of substrate specificity and catalysis.

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