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A brief overview of amyloids and Alzheimer's disease
Author(s) -
Ow SianYang,
Dunstan Dave E.
Publication year - 2014
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1002/pro.2524
Subject(s) - fibril , amyloid fibril , amyloid (mycology) , amyloid disease , disease , protein aggregation , biochemistry of alzheimer's disease , protein folding , chemistry , amyloidosis , alzheimer's disease , amyloid β , biophysics , medicine , amyloid precursor protein , biology , biochemistry , pathology
Amyloid fibrils are self‐assembled fibrous protein aggregates that are associated with a number of presently incurable diseases such as Alzheimer's and Parkinson's disease. Millions of people worldwide suffer from amyloid diseases. This review summarizes the unique cross‐β structure of amyloid fibrils, morphological variations, the kinetics of amyloid fibril formation, and the cytotoxic effects of these fibrils and oligomers. Alzheimer's disease is also explored as an example of an amyloid disease to show the various approaches to treat these amyloid diseases. Finally, this review investigates the nanotechnological and biological applications of amyloid fibrils; as well as a summary of the typical biological pathways involved in the disposal of amyloid fibrils and their precursors.