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Cirrhosis affects maximal oxygen consumption, functional capacity, quality of life in patients with hepatitis C
Author(s) -
Casales da Silva Vieira Rodrigo,
ÁlvaresdaSilva Mario Reis,
Oliveira Álvaro Reischak,
Silveira Gross Julia,
Kruger Renata Lopes,
Dal Bosco Adriane,
Marroni Norma Anair Possa,
Forgiarini Luiz Alberto,
Dias Alexandre Simões
Publication year - 2018
Publication title -
physiotherapy research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 49
eISSN - 1471-2865
pISSN - 1358-2267
DOI - 10.1002/pri.1727
Subject(s) - cirrhosis , medicine , vo2 max , quality of life (healthcare) , gastroenterology , physical therapy , heart rate , blood pressure , nursing
Objective The aim is assess, compare, and correlate maximal oxygen consumption (VO 2max. ), functional capacity and quality of life in cirrhotic patients with hepatitis C virus (HCV) and in healthy individuals. Methods This case–control study included 36 participants (18 patients with HCV cirrhosis and 18 healthy individuals) matched for sex and age. VO 2max was assessed using ergospirometry with an incremental load test on a cycloergometer. Functional capacity was measured by a 6‐min walk test (6WT), and quality of life was assessed using the 36‐Item Short‐Form Health Survey (SF‐36). Results Both the cirrhotic group and the control group had similar results for sex (44.4% male) and age (55.6 ± 8.31 and 55.2 ± 8.85 years, respectively). The cirrhotic group scored lower in all domains of the SF‐36, on the VO 2max test (cirrhotic group 16.2 [11.6–18.6] ml/kg/min; control group 19.9 [16.28–26.9]; p = 0.007) and on the 6WT (cirrhotic group 521.5 [476.25–544.75] m; control group 618.0 [570.75–643.75] m; p = 0.0001). Correlations were found between the 6WT and the VO 2max ( r = 0.801, p < 0.0001) and between the 6WT and quality of life (SF‐361—functional capacity domain; r = 0.552, p = 0.018) only in the cirrhotic group. Conclusion Patients with cirrhosis due to HCV show changes in VO 2max and in functional capacity, which have a significant impact on their quality of life.