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Front Cover: Classification of Inflammatory Bowel Disease from Formalin‐Fixed, Paraffin‐Embedded Tissue Biopsies via Imaging Mass Spectrometry
Author(s) -
Klein Oliver,
Fogt Franz,
Hollerbach Stephan,
Nebrich Grit,
Boskamp Tobias,
Wellmann Axel
Publication year - 2020
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.202070061
Subject(s) - ulcerative colitis , inflammatory bowel disease , medicine , pathology , mass spectrometry imaging , mass spectrometry , crohn's disease , biopsy , gastroenterology , disease , chemistry , chromatography
MALDI mass spectrometry imaging of four discriminative peptides in the two main forms of chronic inflammatory bowel disease, ulcerative colitis and Crohn's disease, as compared to normal patients. In combination with multi‐variate data analysis, this method enables an automated classification of ulcerative colitis, Crohn's disease and normal conditions tissue biopsies. This is reported by Oliver Klein, Franz Fogt, Stephan Hollerbach, Grit Nebrich, Tobias Boskamp, Axel Wellmann in arctile 1900131.