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Front Cover: Cardiomyocyte Proteome Remodeling due to Isoproterenol‐Induced Cardiac Hypertrophy during the Compensated Phase
Author(s) -
Parreira Ricardo Cambraia,
GómezMendoza Diana Paola,
Jesus Itamar Couto Guedes,
Lemos Rafael Pereira,
Santos Anderson Kennedy,
Rezende Cristiana Perdigão,
Figueiredo Henrique César Pereira,
Pinto Mauro Cunha Xavier,
Kjeldsen Frank,
Guatimosim Silvia,
Resende Rodrigo Ribeiro,
VeranoBraga Thiago
Publication year - 2020
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.202070041
Subject(s) - muscle hypertrophy , cardiac hypertrophy , medicine , heart failure , pathological , front cover , cardiology , sympathetic nervous system , cover (algebra) , blood pressure , mechanical engineering , engineering
Abnormal activation of the sympathetic nervous system can induce cardiac hypertrophy and ultimately heart failure. To shed lights into the downstream effectors of the earlier stages of pathological hypertrophy, mice were treated for seven days with isoproterenol and cardiomyocytes isolated from hypertrophic hearts were studied by proteomics. Potential earlier markers for heart failure and therapeutic targets are reported. This is reported by Ricardo Cambraia Parreira, Diana Paola Gómez‐Mendoza, Itamar Couto Guedes de Jesus, Rafael Pereira Lemos, Anderson Kennedy Santos, Cristiana Perdigão Rezende, Henrique César Pereira Figueiredo, Mauro Cunha Xavier Pinto, Frank Kjeldsen, Silvia Guatimosim, Rodrigo Ribeiro Resende, Thiago Verano‐Braga in article 2000017.