Premium
Front Cover: Degradomics in Biomarker Discovery
Author(s) -
Grozdanić Marija,
Vidmar Robert,
Vizovišek Matej,
Fonović Marko
Publication year - 2019
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201970061
Subject(s) - biomarker , biomarker discovery , proteases , front cover , identification (biology) , medicine , body fluid , biological fluids , urine , computational biology , cover (algebra) , biology , proteomics , pathology , chemistry , engineering , mechanical engineering , biochemistry , botany , chromatography , gene , enzyme
The vital role of proteases in the progression of various diseases has been increasingly recognized. Proteolytically generated proteoforms are secreted into body fluids, such as blood, urine, and cerebrospinal fluid which enables their utilisation in biomarker discovery. Degradomic methodologies can be applied for the initial identification and validation of clinically relevant biomarkers, which could be used for monitoring of disease development, progression and therapeutic response. This is reported by Marija Grozdani ć, Robert Vidmar, Matej Vizovićek, and Marko Fonovi ć in article 1800138.