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Front Cover: Integration of “Omics” Strategies for Biomarkers Discovery and for the Elucidation of Molecular Mechanisms Underlying Brugada Syndrome
Author(s) -
Scumaci Domenica,
Oliva Antonio,
Concolino Antonio,
Curcio Antonio,
Fiumara Claudia Vincenza,
Tammè Laura,
Campuzano Oscar,
Pascali Vincenzo L.,
Coll Monica,
Iglesias Anna,
Berne Paola,
Casu Gavino,
Olivo Erika,
Ausania Francesco,
Ricci Pietrantonio,
Indolfi Ciro,
Brugada Josep,
Brugada Ramon,
Cuda Giovanni
Publication year - 2018
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201870050
Subject(s) - brugada syndrome , phenotype , cover (algebra) , computational biology , biology , gene , neuroscience , genetics , engineering , mechanical engineering
The main characteristics of BrS are the peculiar ECG pattern. The study suggests a cooperative activity of mutated genes, deregulated miRNAs and proteins in orchestrating transcriptional and post‐translational events concurring in the development of the Brugada cardiac phenotype. The image summarizes the integration of “‐omics” approaches (genomic, mirnomic and proteomic) in “codifying” the peculiar ECG pattern of Brugada syndrome. This is reported by Domenica Scumaci, Antonio Oliva, Antonio Concolino, Antonio Curcio, Claudia Vincenza Fiumara, Laura Tammè, Oscar Campuzano, Vincenzo L. Pascali, Monica Coll, Anna Iglesias, Paola Berne, Gavino Casu, Erika Olivo, Francesco Ausania, Pietrantonio Ricci, Ciro Indolfi, Josep Brugada, Ramon Brugada, Giovanni Cuda in article number 1800065 .