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Front Cover: Identification of candidate biomarkers for the prediction of gestational diabetes mellitus in the early stages of pregnancy using iTRAQ quantitative proteomics
Author(s) -
Zhao Danqing,
Shen Liming,
Wei Yan,
Xie Jiaming,
Chen Shuqiang,
Liang Yi,
Chen Youjiao,
Wu Haorong
Publication year - 2017
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201770040
Subject(s) - gestational diabetes , pregnancy , medicine , diabetes mellitus , proteomics , endocrinology , gestation , bioinformatics , biology , biochemistry , genetics , gene
DOI: 10.1002/prca.201600152 The picture highlights the roles of complement cascade, clotting cascade, and lipoprotein metabolism in the pathophysiology of gestational diabetes mellitus (GDM). The panel of four proteins (FGA, F9, APOE and IGFBP) can distinguish between women with subsequently developed GDM and controls with high sensitivity and specificity in early stages of pregnancy. This is reported by Danqing Zhao, Liming Shen, Yan Wei, Jiaming Xie, Shuqiang Chen, Yi Liang, Youjiao Chen and Haorong Wu, in article number 1600152.