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Back cover: Imaging mass spectrometry of the visual system: Advancing the molecular understanding of retina degenerations
Author(s) -
Bowrey Hannah E.,
Anderson David M.,
Pallitto Patrick,
Gutierrez Danielle B.,
Fan Jie,
Crouch Rosalie K.,
Schey Kevin L.,
Ablonczy Zsolt
Publication year - 2016
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201670043
Subject(s) - retina , retinal , mass spectrometry imaging , blinding , cover (algebra) , retinal pigment epithelium , mass spectrometry , ophthalmology , medicine , pathology , anatomy , neuroscience , computational biology , biology , chemistry , chromatography , mechanical engineering , engineering , randomized controlled trial
DOI: 10.1002/prca.201500103 Damage associated with the bisretinoid, A2E, has been implicated in blinding diseases. Imaging mass spectrometry of flat mounted retinal pigment epithelial tissue from mice, rabbits, macaques, and humans provided evidence that the distribution of A2E depends on retina and eye anatomy. These comparative data support the idea that elevated levels of A2E are indicative of reduced metabolic activity in the retina. Further details can be found in the article by Hannah E. Bowrey et al. on page 391.