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Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease
Author(s) -
Miyoshi Eiji,
Shinzaki Shinichiro,
Fujii Hironobu,
Iijima Hideki,
Kamada Yoshihiro,
Takehara Tetsuo
Publication year - 2016
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201500089
Subject(s) - glycobiology , pathogenesis , glycosylation , inflammatory bowel disease , immunology , immune system , disease , ulcerative colitis , immunity , inflammation , medicine , biology , glycoprotein , glycan , pathology , genetics
The intestine is one of the most important organs associated with the immune system. It is thought that disruption of intestinal immunity causes inflammatory bowel disease (IBD). Recent advances in immune glycobiology have provided novel insights into many human diseases. For example, studies of glycosylation remodeling in mice have underscored the importance of oligosaccharides in the pathogenesis of IBD. Furthermore, aberrant glycosylation of IgG is a good serum marker of IBD activity. In this review, we examine current understanding of the role of aberrant glycosylation in the pathogenesis of IBD in terms of our original data and recent reports.