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Protein arrays for biomarker discovery in lupus
Author(s) -
Hinchliffe Taylor E.,
Lin ZuanTao,
Wu Tianfu
Publication year - 2016
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201500060
Subject(s) - biomarker discovery , biomarker , systemic lupus erythematosus , computational biology , protein microarray , disease , proteomics , biology , bioinformatics , medicine , dna microarray , pathology , genetics , gene , gene expression
Lupus is one of the most common autoimmune diseases, yet many mechanisms of its pathogenesis are not fully known. Over the last few years, advances in protein array technology have accelerated rapidly, resulting in many promising insights toward the discovery of novel lupus biomarkers that may become useful in disease diagnosis and management. Still, only two types of analytical protein arrays thus far, being antibody and antigen arrays, have found notable usage toward lupus biomarker discovery. In this review, we summarize current protein array technologies being used for biomarker discoveries in lupus and associated biomarker findings, as well as protein arrays that are likely to be used for lupus biomarker discovery in the near future.