Premium
Urinary extracellular vesicles for biomarker source to monitor polycystic kidney disease
Author(s) -
Choi DongSic
Publication year - 2015
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201500053
Subject(s) - extracellular vesicles , proteomics , autosomal dominant polycystic kidney disease , biomarker , vesicle , polycystic kidney disease , urinary system , microvesicles , biomarker discovery , biology , microbiology and biotechnology , kidney , extracellular vesicle , microrna , biochemistry , endocrinology , gene , membrane
Extracellular vesicles (EVs) are bilayered lipid vesicles, 50–1000 nm in diameter and secreted by most types of cells. They contain many proteins, mRNAs, miRNAs, and lipids that reflect the pathophysiological state of the cells they originate from, and are therefore considered to be a rich source of potential biomarkers. In this issue (Pocsfalvi, G. et al., Proteomics Clin. Appl . 2015, 9 , 552–567), Pocsfalvi et al. conducted pioneering investigations to determine whether changes in the protein content of EVs occur during progression of autosomal dominant polycystic kidney disease (ADPKD), a common genetic disorder that predominantly affects the kidneys. Most significantly, iTRAQ‐based quantitative proteomics showed that cytoskeleton‐regulating and Ca 2+ ‐binding proteins are differentially expressed in urinary EVs of ADPKD patients. Impressively, these proteins are involved in biological processes that are closely related to the pathogenic state of tubular epithelial cells in ADPKD, demonstrating the possibility to monitor the status of patients using urinary EVs.