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Autism spectrum disorder: An omics perspective
Author(s) -
Woods Alisa G.,
Wormwood Kelly L.,
Wetie Armand G. Ngounou,
Aslebagh Roshanak,
Crimmins Bernard S.,
Holsen Thomas M.,
Darie Costel C.
Publication year - 2015
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201400116
Subject(s) - autism spectrum disorder , omics , perspective (graphical) , autism , spectrum (functional analysis) , psychology , data science , computational biology , psychiatry , bioinformatics , computer science , biology , artificial intelligence , physics , quantum mechanics
Current directions in autism spectrum disorder (ASD) research may require moving beyond genetic analysis alone, based on the complexity of the disorder, heterogeneity and convergence of genetic alterations at the cellular/functional level. Mass spectrometry (MS) has been increasingly used to study CNS disorders, including ASDs. Proteomic research using MS is directed at understanding endogenous protein changes that occur in ASD. This review focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using MS, including fragile X syndrome (FXS) and Smith‐Lemli‐Opitz Syndrome (SLOS), genetic syndromes highly associated with ASD comorbidity.