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Proteomics in the investigation of HIV‐1 interactions with host proteins
Author(s) -
Li Ming
Publication year - 2015
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201400101
Subject(s) - proteomics , host (biology) , human immunodeficiency virus (hiv) , computational biology , biology , identification (biology) , host factors , virology , virus , genetics , gene , botany
Productive HIV‐1 infection depends on host machinery, including a broad array of cellular proteins. Proteomics has played a significant role in the discovery of HIV‐1 host proteins. In this review, after a brief survey of the HIV‐1 host proteins that were discovered by proteomic analyses, I focus on analyzing the interactions between the virion and host proteins, as well as the technologies and strategies used in those proteomic studies. With the help of proteomics, the identification and characterization of HIV‐1 host proteins can be translated into novel antiretroviral therapeutics.