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Dynamic proteome in enigmatic preeclampsia: An account of molecular mechanisms and biomarker discovery
Author(s) -
Mary Sheon,
Patil Gouri V.,
Kulkarni Asmita V.,
Kulkarni Mahesh J.,
Joshi Sadhana R.,
Mehendale Savita S.,
Giri Ashok P.
Publication year - 2012
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201100089
Subject(s) - proteomics , biomarker , preeclampsia , disease , biomarker discovery , bioinformatics , proteinuria , proteome , genomics , pregnancy , medicine , computational biology , biology , pathology , genome , genetics , kidney , gene
The coevolution of genomics and proteomics has led to advancements in the field of diagnosis and molecular mechanisms of disease. Proteomics is now stepping into the field of obstetrics, where early diagnosis of pregnancy complication such as preeclampsia (PE) is imperative. PE is a multifactorial disease characterized by hypertension with proteinuria, which is a leading cause of maternal and neonatal morbidity and mortality occurring in 5‐7% of pregnancies worldwide. This review discusses the probable molecular mechanisms that lead to PE and summarizes the proteomics research carried out in understanding the pathogenicity of PE, and for identifying the candidate biomarker for diagnosis of the disease.