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Differential proteomics of human seminal plasma: A potential target for searching male infertility marker proteins
Author(s) -
Tomar Anil Kumar,
Sooch Balwinder Singh,
Singh Sarman,
Yadav Savita
Publication year - 2012
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.201100084
Subject(s) - infertility , proteome , proteomics , male infertility , fertility , sperm , semen , biology , human fertilization , bioinformatics , human reproduction , unexplained infertility , andrology , medicine , pregnancy , genetics , population , environmental health , gene
The clinical fertility tests, available in the market, fail to define the exact cause of male infertility in almost half of the cases and point toward a crucial need of developing better ways of infertility investigations. The protein biomarkers may help us toward better understanding of unknown cases of male infertility that, in turn, can guide us to find better therapeutic solutions. Many clinical attempts have been made to identify biomarkers of male infertility in sperm proteome but only few studies have targeted seminal plasma. Human seminal plasma is a rich source of proteins that are essentially required for development of sperm and successful fertilization. This viewpoint article highlights the importance of human seminal plasma proteome in reproductive physiology and suggests that differential proteomics integrated with functional analysis may help us in searching potential biomarkers of male infertility.