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Proteomics of bacterial pathogenicity: Therapeutic implications
Author(s) -
Windle Henry J.,
Brown Paul A.,
Kelleher Dermot P.
Publication year - 2010
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.200900145
Subject(s) - proteomics , identification (biology) , proteome , computational biology , infectious disease (medical specialty) , biology , pathogenicity , biomarker discovery , pathogen , disease , bioinformatics , medicine , immunology , microbiology and biotechnology , genetics , ecology , pathology , gene
Identification of the molecular mechanisms of host–pathogen interaction is becoming a key focus of proteomics. Analysis of these interactions holds promise for significant developments in the identification of new therapeutic strategies to combat infectious diseases, a process that will also benefit parallel improvements in molecular diagnostics, biomarker identification and drug discovery. This review highlights recent advances in functional proteomics initiatives in infectious disease with emphasis on studies undertaken within physiologically relevant parameters that enable identification of the infectious proteome rather than that of the vegetative state. Deciphering the molecular details of what constitutes physiologically relevant host–pathogen interactions remains an underdeveloped aspect of research into infectious disease. The magnitude of this deficit will be largely influenced by the ease with which model systems can be established to investigate such interactions. As the selective pressures exerted by the host on an infecting pathogen are numerous, the adequacy of certain model systems should be considered carefully.