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The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid
Author(s) -
Mason Stephen B.,
Lai Xianyin,
Bacallao Robert L.,
BlazerYost Bonnie L.,
Gattone Vincent H.,
Wang Kevin C.,
Witzmann Frank A.
Publication year - 2009
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.200800163
Subject(s) - autosomal dominant polycystic kidney disease , biomarker , cyst , proteome , polycystic kidney disease , kidney , biology , diagnostic biomarker , pathology , disease , biomarker discovery , medicine , computational biology , bioinformatics , proteomics , endocrinology , genetics , gene
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid‐filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow‐up experiment, we hypothesized that the protein‐bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.