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Lectin microarray
Author(s) -
Hu Shen,
Wong David T.
Publication year - 2009
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.200800153
Subject(s) - lectin , glycomics , glycan , glycoprotein , microarray , microarray analysis techniques , computational biology , microbiology and biotechnology , chemistry , biology , biochemistry , gene , gene expression
Lectin microarray is a new technology that utilizes a panel of lectins immobilized on well‐defined substrate for high‐throughout analysis of glycans and glycoproteins. In this article, we have reviewed the fabrication and detection schemes in lectin microarray and discussed its novel applications in glycomics. We have also demonstrated a lectin array on PDMS with MALDI‐TOF‐MS for glycoprotein analysis. This method has been demonstrated for differential analysis of serum glycoproteins in oral cancer and healthy control subjects.