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Proneurotensin/neuromedin N secreted from small cell lung carcinoma cell lines as a potential tumor marker
Author(s) -
Ogura Shunichiro,
Kaneko Kumi,
Miyajima Shoji,
Ohshima Keiichi,
Yamaguchi Ken,
Mochizuki Tohru
Publication year - 2008
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.200800039
Subject(s) - cell culture , cell , small cell lung carcinoma , carcinoma , lung cancer , carcinoma cell , large cell , cancer research , lung , biology , tumor marker , pathology , small cell carcinoma , cancer , chemistry , medicine , adenocarcinoma , biochemistry , genetics
Proteins secreted from specific cancer cells have a high potential for use as tumor markers. We identified secreted proteins produced by 15 different carcinoma cell lines grown in serum‐free medium using MS/MS. Proneurotensin/neuromedin N (proNT/NMN) was found in conditioned medium from four of seven small cell lung carcinoma cell lines but not from eight nonsmall cell lung carcinoma cell lines. These results indicate proNT/NMN has potential as a specific tumor marker of small cell lung carcinoma.