Proneurotensin/neuromedin N secreted from small cell lung carcinoma cell lines as a potential tumor marker | Zendy

Ogura Shunichiro | Zendy; Kaneko Kumi | Zendy; Miyajima Shoji | Zendy; Ohshima Keiichi | Zendy; Yamaguchi Ken | Zendy; Mochizuki Tohru | Zendy

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Proneurotensin/neuromedin N secreted from small cell lung carcinoma cell lines as a potential tumor marker

Author(s) -

Ogura Shunichiro,

Kaneko Kumi,

Miyajima Shoji,

Ohshima Keiichi,

Yamaguchi Ken,

Mochizuki Tohru

Publication year - 2008

Publication title -

proteomics – clinical applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.948

H-Index - 54

eISSN - 1862-8354

pISSN - 1862-8346

DOI - 10.1002/prca.200800039

Subject(s) - cell culture , cell , small cell lung carcinoma , carcinoma , lung cancer , carcinoma cell , large cell , cancer research , lung , biology , tumor marker , pathology , small cell carcinoma , cancer , chemistry , medicine , adenocarcinoma , biochemistry , genetics

Proteins secreted from specific cancer cells have a high potential for use as tumor markers. We identified secreted proteins produced by 15 different carcinoma cell lines grown in serum‐free medium using MS/MS. Proneurotensin/neuromedin N (proNT/NMN) was found in conditioned medium from four of seven small cell lung carcinoma cell lines but not from eight nonsmall cell lung carcinoma cell lines. These results indicate proNT/NMN has potential as a specific tumor marker of small cell lung carcinoma.

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