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Proteomic insights into cardiac cell death and survival
Author(s) -
MacLellan W. Robb,
Wang Yibin,
Vondriska Thomas M.,
Weiss James N.,
Ping Peipei
Publication year - 2008
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.200780121
Subject(s) - proteomics , disease , cardiac cell , cause of death , biology , systems biology , phenotype , programmed cell death , clinical phenotype , neuroscience , bioinformatics , computational biology , medicine , pathology , microbiology and biotechnology , genetics , apoptosis , gene
Cardiovascular disease is the leading cause of death and disability in the developed world. To design novel therapeutic strategies to treat and prevent this disease, better understanding of cardiac cell function is necessary. In addition to (and, indeed, in combination with) genetics, physiology and molecular biology, proteomics plays a critical role in our understanding of cardiovascular systems at multiple scales. The purpose of this review is to examine recent developments in the field of myocardial injury and protection, examining how proteomics has informed investigations into organelles, signaling complexes, and cardiac phenotype.