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Human kidney glomerulus proteome and biomarker discovery of kidney diseases
Author(s) -
Yoshida Yutaka,
Miyamoto Masahito,
Taguchi Izumi,
Xu Bo,
Zhang Ying,
Yaoita Eishin,
Fujinaka Hidehiko,
Yamamoto Tadashi
Publication year - 2008
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.200780016
Subject(s) - glomerulus , biomarker , proteomics , biomarker discovery , kidney , renal function , medicine , podocyte , proteome , kidney glomerulus , renal glomerulus , pathology , kidney disease , glomerulonephritis , bioinformatics , biology , proteinuria , biochemistry , gene
The kidney glomerulus is the site of plasma filtration and production of primary urine in the kidney. The structure not only plays a pivotal role in ultrafiltration of plasma into urine but also is the locus of kidney diseases progressing to chronic renal failure. Patients afflicted with these glomerular diseases frequently progress to irreversible loss of renal function and inevitably require replacement therapies. The diagnosis and treatment of glomerular diseases are now based on clinical manifestations, urinary protein excretion level, and renal pathology of needle biopsy specimens. The molecular mechanisms underlying the progression of glomerular diseases are still obscure despite a great number of clinical and experimental studies. Proteomics is a particularly promising approach for the discovery of proteins relevant to physiological and pathophysiological processes, and has been recently employed in nephrology. Although until now most efforts of proteomic analysis have been conducted with urine, the biological fluid that is easily collected without invasive procedures, proteomic analysis of the glomerulus, the tissue most proximal to the disease loci, is the most straightforward approach. In this review, we attempt to outline the current status of clinical proteomics of the glomerulus and provide a perspective of protein biomarker discovery of glomerular diseases.