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The significance of organellar proteomics for the nervous system
Author(s) -
Miller Linda C.,
Sossin Wayne S.
Publication year - 2007
Publication title -
proteomics – clinical applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 54
eISSN - 1862-8354
pISSN - 1862-8346
DOI - 10.1002/prca.200700366
Subject(s) - proteomics , proteome , nervous system , organelle , biology , function (biology) , synaptic vesicle , neuroscience , computational biology , vesicle , microbiology and biotechnology , bioinformatics , biochemistry , membrane , gene
Organellar proteomics is a useful tool for gaining biological insights about structures in the cell. Here, we discuss the tools used in organellar proteomics and the impact of this technique in understanding nervous system function. We will review insights gained from the proteomes of nervous system‐specific organelles such as synaptic vesicles and the postsynaptic density. Moreover, we will show how comparison of proteomes between organelles isolated from the nervous system and from other tissues highlight nervous system‐specific functions using the examples of clathrin‐coated vesicles and RNA granules.