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Comparison of computed tomography (CT) findings with RT‐PCR in the diagnosis of COVID‐19 in children
Author(s) -
Bağcı Zafer,
Keçeli Avni Merter
Publication year - 2021
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.25426
Subject(s) - medicine , covid-19 , computed tomography , retrospective cohort study , pcr test , radiology , nuclear medicine , polymerase chain reaction , disease , infectious disease (medical specialty) , biochemistry , chemistry , gene
Aim This study aimed to compare chest computed tomography (CT) findings with reverse‐transcription polymerase chain reaction (RT‐PCR) test results in children with probable or definitive diagnosis of coronavirus disease 2019 (COVID‐19). Methods In this retrospective archive study, pediatric patients who were followed up in the hospital with a possible or definitive diagnosis of COVID‐19 and who had chest CT at presentation were included. CT scan images of the patients were reinterpreted by a pediatric radiologist and compared with their RT‐PCR test results. Results Of the total of 89 patients, 33 had negative and 56 had positive RT‐PCR tests. The presence of pulmonary lesions and consolidation was statistically significantly higher in the RT‐PCR negative group than in the RT‐PCR positive group ( p = 0.037 and 0.001, respectively). Lobe involvement of 0%–25% was higher in the RT‐PCR positive group ( p = 0.001), and lobe involvements of 25%–50% and 50%–75% were significantly higher in the RT‐PCR negative group ( p = 0.001 and 0.005, respectively). Central and perihilar involvement was found to be statistically significant in the RT‐PCR negative group ( p = 0.008 and 0.005, respectively). Conclusion Chest CT findings may provide some clues in predicting RT‐PCR positivity in children with a probable diagnosis of COVID‐19. Lobe involvement percentage of up to 25% is a finding in favor of patients with positive RT‐PCR test, whereas 25%–75% lobe involvement, central and perihilar involvement, and consolidation can be interpreted in favor of patients with negative RT‐PCR test.