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Thoracoabdominal asynchrony and paradoxical motion in Duchenne muscular dystrophy and healthy subjects during cough: A case control study
Author(s) -
Marques Layana,
Fregonezi Guilherme Augusto de Freitas,
Marcelino Ana Aline,
DouradoJúnior Mario Emílio Teixeira,
Sarmento Antonio,
Pennati Francesca,
Aliverti Andrea,
Resqueti Vanessa Regiane
Publication year - 2021
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.25412
Subject(s) - supine position , medicine , duchenne muscular dystrophy , sitting , cardiology , anesthesia , pathology
Abstract Objective To assess thoracoabdominal asynchrony (TAA) and inspiratory paradoxical motion at different positionings in subjects with Duchenne muscular dystrophy (DMD) versus healthy subjects during quiet spontaneous breathing (QB) and cough. Methods This is a case control study with a matched‐pair design. We assessed 14 DMD subjects and 12 controls using optoelectronic plethysmography (OEP) during QB and spontaneous cough in 3 positions: supine, supine with headrest raised at 45°, and sitting with back support at 80°. The TAA was assessed using phase angle (θ) between upper (RCp) and lower rib cage (RCa) and abdomen (AB), as well as the percentage of inspiratory time the RCp (IP RCp ), RCa (IP RCa ), and AB (IP AB ) moved in opposite directions. Results During cough, DMD group showed higher RCp and RCa θ ( p < .05), RCp and AB θ ( p < .05) in supine and 45° positions, and higher RCp and Rca θ ( p = .006) only in supine position compared with controls. Regarding the intragroup analysis, during cough, DMD group presented higher RCp and AB θ ( p = .02) and RCa and AB θ ( p = .002) in supine and higher RCa and AB θ ( p = .002) in 45° position when compared to 80°. Receiver operating characteristic curve analyzes were able to discriminate TAA between controls and DMD in RCa supine position (area under the curve: 0.81, sensibility: 78.6% and specificity: 91.7%, p = .001). Conclusion Subjects with DMD yields TAA with insufficient deflation of chest wall compartments and rib cage distortion during cough, by noninvasive assessment.