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Cerebral and splanchnic oxygenation during automated control of inspired oxygen (FiO 2 ) in preterm infants
Author(s) -
Dani Carlo,
Pratesi Simone,
Luzzati Michele,
Petrolini Chiara,
Montano Simona,
Remaschi Giulia,
Coviello Caterina
Publication year - 2021
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.25379
Subject(s) - medicine , oxygenation , hypoxemia , splanchnic , gestational age , anesthesia , cohort , fraction of inspired oxygen , retinopathy of prematurity , hemodynamics , mechanical ventilation , pregnancy , biology , genetics
Objectives Our aim in this study was to assess the effect of the Predictive Intelligent Control of Oxygenation (PRICO ® ) system on cerebral (rSO 2 C) and splanchnic (rSO 2 S) oxygenation in a cohort of preterm infants with frequent desaturations. Methods Twenty infants with gestational age <32 weeks ( n = 20) were assigned in random sequence to 12 h of automated or manual adjustment of FiO 2 . Over this period, they were studied continuously by near‐infrared spectroscopy (NIRS). Results We found that rSO 2 C [68.0% (60.5%–74.7%) vs. 68.5% (62%–72%); p = .824] and rSO 2 S [27.0% (17.3%–45.7%) vs. 27.0% (15%–53%); p = .878] were similar during automatic and manual control of FiO 2 . Time spent with SpO 2 90%–95% was higher during the automatic than manual control of FiO 2 , while time spent with SpO 2 <80% or >95% was lower. Conclusions Automated control of FiO 2 with PRICO ® system did not improve brain and splanchnic oxygenation in comparison with manual control in a cohort of preterm infants, but it significantly decreased SpO 2 fluctuations and limited the duration of both hypoxemia and hyperoxemia.