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Pulmonary diffusing capacity measured by NO/CO transfer in Tunisian boys
Author(s) -
Dridi Rim,
Dridi Nadia,
Ben Moussa Zouita Amira,
Muller Paulo T.,
Tabka Zouhair,
Guénard Hervé,
Laher Ismail,
Hackney Anthony C.,
Zouhal Hassane
Publication year - 2020
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24984
Subject(s) - diffusing capacity , pulmonary diffusing capacity , transfer factor , medicine , linear regression , body weight , lung volumes , carbon monoxide , volume (thermodynamics) , reference values , zoology , cardiology , lung , statistics , mathematics , thermodynamics , chemistry , lung function , physics , biochemistry , biology , immunology , catalysis
Background The diffusing capacity, which measures gas‐exchange, uses reference values based on data from American or European studies. There are currently no reference values of pulmonary diffusing capacity (TL) and its components, such as the conductance of the membrane (Dm) and capillary lung volume (Vc) for healthy North African children. Objectives We determined the prediction equations—reference values for TL, Dm, Vc and the alveolar volume (VA) in healthy Tunisian boys. Methods Values of Vc, Dm, TL, and VA were measured by the NO/CO transfer method, using a single breath maneuver in 118 Tunisian boys (8‐14 years old) at rest. We performed linear regression analysis of the pulmonary parameters and independent variables, such as height, weight, and age. Results The reference equations for pulmonary diffusing capacity for carbon monoxide (TL CO ) was 0.201 × weight (kg) + 8.979; for TL NO was 0.76 × height (cm)‐24.383; for Dm was 0.388 × height (cm)‐ 12.555 and for VA was 0.34 × height (cm)‐3.951. Vc increased significantly with weight ( P < .05) but not with age ( P > .05). Conclusions References norms for TL CO and TL for nitric oxide and its components in young Tunisian boys are similar to data from other countries. The prediction equations we developed can be extended to clinical practice in Tunisia and can be considered for use in neighboring North African countries.