Premium
Nasal high‐frequency percussive ventilation vs nasal continuous positive airway pressure in newborn infants respiratory distress: A cross over clinical trial
Author(s) -
Renesme Laurent,
Dumas de la Roque Eric,
Germain Christine,
Chevrier Agnès,
Rebola Muriel,
Cramaregeas Sophie,
Benard Antoine,
Elleau Christophe,
Tandonnet Olivier
Publication year - 2020
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24935
Subject(s) - medicine , continuous positive airway pressure , respiratory distress , anesthesia , gestational age , crossover study , ventilation (architecture) , fraction of inspired oxygen , confidence interval , high frequency ventilation , randomized controlled trial , mechanical ventilation , surgery , pregnancy , placebo , mechanical engineering , alternative medicine , engineering , pathology , biology , obstructive sleep apnea , genetics
Objective To determine if nasal high‐frequency percussive ventilation (nHFPV) to manage neonatal respiratory distress decreases the regional cerebral oxygen saturation (rScO 2 ) compared to nasal continous positive airway pressure (nCPAP). Study Design A prospective, randomized, monocentric, open‐label, noninferiority crossover trial. Newborns of gestational age (GA) ≥ 33 weeks exhibiting persistent respiratory distress after 10 minutes of life were treated with nHFPV and nCPAP, in succession and in random order. The primary endpoint was the mean rScO 2 , as revealed by near‐infrared spectroscopy (NIRS). Results Forty‐nine newborns were randomized; the mean GA and birth weight was 36.4 ± 1.9 weeks and 2718 ± 497 g. The mean rScO 2 difference during the last 5 minutes of each ventilation mode (nHFPV minus nCPAP) was –0.7 ± 5.4% (95% confidence interval (CI) –2.25; 0.95%). Conclusion In our study on newborns of GA ≥33 weeks treated for respiratory distress, cerebral oxygenation via nHFPV was not inferior to nCPAP.