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Impact at school age of early chronic methicillin‐sensitive Staphylococcus aureus infection in children with cystic fibrosis
Author(s) -
Galodé François,
Dournes Gael,
Chateil JeanFrançois,
Fayon Michael,
Collet Cyrielle,
Bui Stéphanie
Publication year - 2020
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24906
Subject(s) - medicine , bronchiectasis , cystic fibrosis , staphylococcus aureus , gastroenterology , respiratory disease , lung , bacteria , biology , genetics
Background Bacterial infection early in life may increase structural lung lesions in children with cystic fibrosis (CF). Methods A 9‐year monocentric (Bordeaux University Hospital, France) retrospective study in children with CF to evaluate the impact of the early‐onset (at 1 year of age, Y1) of chronic meticillin‐sensitive Staphylococcus aureus (MSSA) infection on the severity of bronchiectasis and Bhalla score on CT scan, clinical status, lung function tests, and serum immunoglobulins (IgG) at the age of 6 years (Y6). Results A total of 37 children were included: 10 had contracted chronic MSSA infection at Y1 and 27 at a later date. Children with MSSA infection at Y1 showed increased Y6 CT scan bronchiectasis severity scores vs late MSSA infection (mean ± SD: 4.7 ± 0.8 vs 2.5 ± 0.5, P < .05) and Bhalla scores (7.3 ± 1.1 vs 4.7 ± 0.8, P < .05), but no significant decrease in lung function ([% reference values] FEV1: 83.7 ± 6 vs 90.6 ± 2.2, P = .21; FEF25‐75: 67.8 ± 8.9 vs 76.3 ± 3.9, P = .18). In addition, Y6 serum IgG was greater in the early chronic Y1 MSSA group (11.3 ± 0.7 vs 8.9 ± 0.7 g/L, P < .05). Clinical symptoms or nutritional status were similar in both infection groups. Conclusion Early chronic MSSA infection may enhance the progression of structural lung disease in CF at 6 years.